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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
Acc ID: CHEBI:9334
Term: sulfasalazine
Definition: An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Chemical ID: MESH:D012460
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2affects transportISOABCG2 (Homo sapiens)6480464CTDABCG2 gene polymorphism affects the transport of SulfasalazinePMID:18167504 PMID:18408567
Abcg2decreases methylationISOABCG2 (Homo sapiens)6480464CTDSulfasalazine results in decreased methylation of ABCG2 promoterPMID:20019844
Abcg2increases activityISOABCG2 (Homo sapiens)6480464CTDSulfasalazine results in increased activity of ABCG2 proteinPMID:27475308 PMID:30083819
Abcg2increases transportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in increased transport of SulfasalazinePMID:18167504 PMID:18408567
Abcg2multiple interactionsISOABCG2 (Homo sapiens)6480464CTD[Sulfasalazine results in decreased methylation of ABCG2 promoter] which results in increased expression of ABCG2 mRNA; Dactinomycin inhibits the reaction [Sulfasalazine results in increased expression of ABCG2 mRNA]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Sulfasalazine promotes the reaction [Cholesterol results in increased activity of ABCG2 protein]; yu ping feng san inhibits the reaction [Sulfasalazine results in increased activity of ABCG2 protein]PMID:20019844 PMID:27475308 PMID:32003934 PMID:34135758
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