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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abca1
Name: ATP binding cassette subfamily A member 1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abca1decreases expressionEXP 6480464CTDSimvastatin results in decreased expression of ABCA1 mRNAPMID:25055962
Abca1decreases expressionISOAbca1 (Mus musculus)6480464CTDSimvastatin results in decreased expression of ABCA1 mRNAPMID:22120639
Abca1decreases expressionISOABCA1 (Homo sapiens)6480464CTDSimvastatin results in decreased expression of ABCA1; Simvastatin results in decreased expression of ABCA1 mRNAPMID:19383813 PMID:19461118
Abca1increases expressionISOAbca1 (Mus musculus)6480464CTDSimvastatin results in increased expression of ABCA1 mRNA; Simvastatin results in increased expression of ABCA1 proteinPMID:16282522 PMID:21241519
Abca1increases expressionISOABCA1 (Homo sapiens)6480464CTDSimvastatin results in increased expression of ABCA1 mRNAPMID:18270459
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