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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628895
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aurka
Name: aurora kinase A
Acc ID: CHEBI:61076
Term: belinostat
Definition: A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.
Chemical ID: MESH:C487081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aurkadecreases activityISOAURKA (Homo sapiens)6480464CTDbelinostat results in decreased activity of AURKA proteinPMID:19606018
Aurkadecreases expressionISOAURKA (Homo sapiens)6480464CTDbelinostat results in decreased expression of AURKA mRNA; belinostat results in decreased expression of AURKA proteinPMID:19606018
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