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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptk2b
Name: protein tyrosine kinase 2 beta
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptk2baffects methylationISOPTK2B (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PTK2B 5' UTR; Benzo(a)pyrene affects the methylation of PTK2B exon; Benzo(a)pyrene affects the methylation of PTK2B promoterPMID:27901495 PMID:30157460
Ptk2bdecreases expressionISOPTK2B (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PTK2B mRNAPMID:32234424
Ptk2bincreases expressionISOPtk2b (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of PTK2B mRNAPMID:22228805
Ptk2bincreases methylationISOPtk2b (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of PTK2B exon; Benzo(a)pyrene results in increased methylation of PTK2B intronPMID:27901495
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