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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628748
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adipoq
Name: adiponectin, C1Q and collagen domain containing
Acc ID: CHEBI:63621
Term: saquinavir
Definition: An aspartic acid derivative obtained by formal condensation of the primary amino group of (2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-ylamine with the carboxy group of N(2)(-quinolin-2-ylcarbonyl)-L-asparagine. An inhibitor of HIV-1 protease.
Chemical ID: MESH:D019258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adipoqdecreases expressionISOAdipoq (Mus musculus)6480464CTDSaquinavir results in decreased expression of ADIPOQ mRNA; Saquinavir results in decreased expression of ADIPOQ proteinPMID:15865214
Adipoqmultiple interactionsISOAdipoq (Mus musculus)6480464CTD[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ADIPOQ mRNA; rosiglitazone inhibits the reaction [Saquinavir results in decreased secretion of ADIPOQ protein]PMID:15865214 PMID:16931933
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