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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628673
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dgat1
Name: diacylglycerol O-acyltransferase 1
Acc ID: CHEBI:3749
Term: clofazimine
Definition: 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Chemical ID: MESH:D002991
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dgat1decreases expressionEXP 6480464CTDClofazimine results in decreased expression of DGAT1 mRNAPMID:31393584
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