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ONTOLOGY REPORT - ANNOTATIONS
Term:clofazimine
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Accession:CHEBI:3749 term browser browse the term
Definition:3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.
Synonyms:exact_synonym: N,5-bis(4-chlorophenyl)-3-(propan-2-ylimino)-3,5-dihydrophenazin-2-amine
 related_synonym: (4-Chloro-phenyl)-[5-(4-chloro-phenyl)-3-isopropylimino-3,5-dihydro-phenazin-2-yl]-amine;   3-(p-chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine;   3-(p-chloranilino)-10-(p-chlorphenyl)-2,10-dihydro-2-(isopropylimino)-phenazin;   Formula=C27H22Cl2N4;   InChI=1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3;   InChIKey=WDQPAMHFFCXSNU-UHFFFAOYSA-N;   N,5-bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydrophenazin-2-amine;   SMILES=CC(C)N=c1cc2n(-c3ccc(Cl)cc3)c3ccccc3nc2cc1Nc1ccc(Cl)cc1;   clofazimina;   clofaziminum
 alt_id: CHEBI:355347
 xref: Beilstein:8168151 "Beilstein";   CAS:2030-63-9 "ChemIDplus";   CAS:2030-63-9 "KEGG COMPOUND";   DrugBank:DB00845;   KEGG:C06915;   KEGG:D00278;   LINCS:LSM-5669
 xref_mesh: MESH:D002991
 xref: PMID:17210775 "ChEMBL";   PMID:3279207 "ChEMBL";   Patent:US2948726

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clofazimine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
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  CHEBI ontology 19654
    role 19598
      application 19220
        dye 1236
          clofazimine 3
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  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic molecule 19327
                              organic cyclic compound 19076
                                carbocyclic compound 17501
                                  benzenoid aromatic compound 17022
                                    benzenes 16737
                                      chlorobenzenes 12573
                                        monochlorobenzenes 8721
                                          clofazimine 3
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