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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b3decreases activityISOCYP2B6 (Homo sapiens)6480464CTDKetoconazole results in decreased activity of CYP2B6 proteinPMID:14709627
Cyp2b3decreases activityISOCyp2b10 (Mus musculus)6480464CTDKetoconazole results in decreased activity of CYP2B10 proteinPMID:18420780
Cyp2b3increases expressionISOCyp2b10 (Mus musculus)6480464CTDKetoconazole results in increased expression of CYP2B10 mRNAPMID:17966066
Cyp2b3multiple interactionsISOCYP2B6 (Homo sapiens)6480464CTDKetoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]PMID:16608920 PMID:17438109
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