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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b3decreases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP2B3 mRNAPMID:19692669
Cyp2b3increases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2B3 mRNAPMID:34256052
Cyp2b3multiple interactionsEXP 6480464CTDAHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2B3 mRNA]PMID:34256052
Cyp2b3increases expressionISOCYP2B6 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2B6 mRNAPMID:19692669
Cyp2b3increases expressionISOCyp2b10 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2B10 mRNAPMID:30312631
Cyp2b3multiple interactionsISOCyp2b10 (Mus musculus)6480464CTD3,4,5,3',4'-pentachlorobiphenyl affects the reaction [aroclor 1260 results in increased expression of CYP2B10 mRNA]; aroclor 1260 promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2B10 mRNA]PMID:30312631
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