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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62387
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdx1
Name: pancreatic and duodenal homeobox 1
Acc ID: CHEBI:64206
Term: bromochloroacetic acid
Definition: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by bromine while a second is replaced by chlorine. A low-melting (27.5-31.5degreeC), hygroscopic crystalline solid, it can be formed during the disinfection (by chlorination) of water that contains bromide ions and organic matter, so can occur in drinking water as a byproduct of the disinfection process.
Chemical ID: MESH:C099813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdx1decreases expressionISOPdx1 (Mus musculus)6480464CTDbromochloroacetic acid results in decreased expression of IPF1 proteinPMID:21296659
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