GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pdx1 | affects expression | EXP | | 6480464 | CTD | Glucose affects the expression of PDX1 mRNA | PMID:24349266 | Pdx1 | decreases expression | EXP | | 6480464 | CTD | Glucose results in decreased expression of PDX1 protein | PMID:24349266 | Pdx1 | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of PDX1 mRNA | PMID:22558381 | Pdx1 | multiple interactions | EXP | | 6480464 | CTD | lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA] | PMID:22558381 | Pdx1 | affects localization | ISO | PDX1 (Homo sapiens) | 6480464 | CTD | Glucose affects the localization of PDX1 protein | PMID:11574405 PMID:22558381 PMID:9873045 | Pdx1 | affects localization | ISO | Pdx1 (Mus musculus) | 6480464 | CTD | Glucose affects the localization of PDX1 protein | PMID:11574405 PMID:9873045 | Pdx1 | increases activity | ISO | Pdx1 (Mus musculus) | 6480464 | CTD | Glucose results in increased activity of PDX1 promoter | PMID:16489446 | Pdx1 | increases expression | ISO | Pdx1 (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of PDX1 mRNA | PMID:22558381 | Pdx1 | multiple interactions | ISO | PDX1 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of PDX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]; [Glucose co-treated with INS protein] affects the localization of PDX1 protein; [Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein; [SB 203580 co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; [wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; calyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein]; Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein; Okadaic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]; Palmitic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]; SB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]; SB 203580 inhibits the reaction [Glucose affects the localization of PDX1 protein]; SB 203580 inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]; wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]; wortmannin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein] | PMID:11574405 PMID:22558381 PMID:9873045 | Pdx1 | multiple interactions | ISO | Pdx1 (Mus musculus) | 6480464 | CTD | [copper bis(3,5-diisopropylsalicylate) co-treated with Glucose] results in increased expression of PDX1 protein; [ebselen co-treated with Glucose] results in increased expression of PDX1 protein; [Glucose co-treated with INS1 protein] affects the localization of PDX1 protein; [Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein; [Metformin co-treated with Glucose] affects the localization of PDX1 protein; calyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein]; Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein; IL1B protein inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]; Okadaic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]; Palmitic Acid inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]; PDX1 protein affects the reaction [bisphenol A promotes the reaction [Glucose results in increased secretion of INS protein]]; rosiglitazone promotes the reaction [Glucose results in increased activity of PDX1 promoter]; SB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]; SB 203580 inhibits the reaction [Glucose affects the localization of PDX1 protein]; TLR4 affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]]; wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein] | PMID:11574405 PMID:16489446 PMID:22558381 PMID:23795780 PMID:28774890 PMID:9873045 | | ||||||||||||||||||||||
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