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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62368
Species: Mus musculus
RGD Object: Gene
Symbol: Ptges
Name: prostaglandin E synthase
Acc ID: CHEBI:34674
Term: dextran sulfate
Definition: A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units.
Chemical ID: MESH:D016264
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgesincreases expressionEXP 6480464CTDDextran Sulfate results in increased expression of PTGES proteinPMID:20132809 PMID:30489199 PMID:36543318
Ptgesmultiple interactionsEXP 6480464CTD7-hydroxyl-1-methylindole-3-acetonitrile inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein]; [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PTGES mRNA; Fatty Acids, Omega-3 inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein]; Mesalamine inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein]; Resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein]PMID:20132809 PMID:29950665 PMID:30489199 PMID:36543318
Ptgesincreases expressionISOPtges (Rattus norvegicus)6480464CTDDextran Sulfate results in increased expression of PTGES proteinPMID:19228061
Ptgesmultiple interactionsISOPtges (Rattus norvegicus)6480464CTDresveratrol inhibits the reaction [Dextran Sulfate results in increased expression of PTGES protein]PMID:19228061
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