GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Txnrd1 | increases activity | EXP | | 6480464 | CTD | Sodium Selenite results in increased activity of TXNRD1 protein | PMID:18215477 | Txnrd1 | multiple interactions | EXP | | 6480464 | CTD | Sodium Selenite promotes the reaction [arsenic acid results in increased activity of TXNRD1 protein]; Sodium Selenite promotes the reaction [arsenite results in increased activity of TXNRD1 protein] | PMID:19429247 | Txnrd1 | affects expression | ISO | Txnrd1 (Rattus norvegicus) | 6480464 | CTD | Sodium Selenite affects the expression of TXNRD1 | PMID:18209489 | Txnrd1 | decreases activity | ISO | TXNRD1 (Homo sapiens) | 6480464 | CTD | Sodium Selenite results in decreased activity of TXNRD1 protein | PMID:18405881 | Txnrd1 | decreases expression | ISO | TXNRD1 (Homo sapiens) | 6480464 | CTD | Sodium Selenite results in decreased expression of TXNRD1 protein | PMID:18405881 | Txnrd1 | increases activity | ISO | Txnrd1 (Rattus norvegicus) | 6480464 | CTD | Sodium Selenite results in increased activity of TXNRD1 protein | PMID:12449240 | Txnrd1 | increases activity | ISO | TXNRD1 (Homo sapiens) | 6480464 | CTD | Sodium Selenite results in increased activity of TXNRD1 protein | PMID:12663510 PMID:12949356 PMID:18405881 PMID:19486940 PMID:24816296 | Txnrd1 | increases expression | ISO | Txnrd1 (Rattus norvegicus) | 6480464 | CTD | Sodium Selenite results in increased expression of TXNRD1 mRNA | PMID:12449240 | Txnrd1 | increases expression | ISO | TXNRD1 (Homo sapiens) | 6480464 | CTD | Sodium Selenite results in increased expression of TXNRD1 mRNA; Sodium Selenite results in increased expression of TXNRD1 mRNA alternative form; Sodium Selenite results in increased expression of TXNRD1 protein | PMID:12663510 PMID:18405881 PMID:19486940 PMID:24383545 PMID:24816296 PMID:31585128 | Txnrd1 | increases oxidation | ISO | TXNRD1 (Homo sapiens) | 6480464 | CTD | Sodium Selenite results in increased oxidation of TXNRD1 protein | PMID:19486940 | Txnrd1 | multiple interactions | ISO | Txnrd1 (Rattus norvegicus) | 6480464 | CTD | [Sodium Selenite co-treated with NADP] inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]; Sodium Selenite inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Sodium Selenite inhibits the reaction [cholestane-3,5,6-triol results in increased expression of TXNRD1 mRNA]; Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of TXNRD1 protein]; Sodium Selenite inhibits the reaction [sodium arsenite results in decreased expression of TXNRD1 mRNA] | PMID:16039982 PMID:20457604 PMID:20810785 PMID:23603382 PMID:28544404 | Txnrd1 | multiple interactions | ISO | TXNRD1 (Homo sapiens) | 6480464 | CTD | [Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of TXNRD1 mRNA; [Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in decreased expression of TXNRD1 protein; [sulforaphane co-treated with Sodium Selenite] results in increased activity of TXNRD1 protein; Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]; Auranofin promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]; Buthionine Sulfoximine promotes the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]; Mercuric Chloride promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]; methylmercuric chloride inhibits the reaction [Sodium Selenite results in increased expression of TXNRD1 protein]; Sodium Selenite inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]; Sodium Selenite promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]; Sodium Selenite promotes the reaction [Mercuric Chloride results in increased expression of TXNRD1 mRNA]; Sodium Selenite promotes the reaction [Mercuric Chloride results in increased expression of TXNRD1 protein]; Sodium Selenite promotes the reaction [sulforaphane results in increased activity of TXNRD1 protein]; Sodium Selenite promotes the reaction [sulforaphane results in increased expression of TXNRD1 mRNA]; Sodium Selenite promotes the reaction [sulforaphane results in increased expression of TXNRD1 protein]; Sodium Selenite promotes the reaction [TXNRD1 protein results in increased susceptibility to (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane]; Sodium Selenite results in increased expression of and results in increased activity of TXNRD1 protein | PMID:12663510 PMID:12949356 PMID:19486940 PMID:20810785 PMID:24816296 PMID:25179160 PMID:28757135 | | ||||||||||||||||||||||
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