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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62221
Species: Mus musculus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1adecreases expressionISOHIF1A (Homo sapiens)6480464CTDChlorpyrifos results in decreased expression of HIF1A mRNAPMID:31509763
Hif1aincreases expressionISOHIF1A (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of HIF1A proteinPMID:38844257
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTDalpha-naphthoflavone inhibits the reaction [Chlorpyrifos results in increased expression of HIF1A protein]PMID:38844257
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