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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621882
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scarb2
Name: scavenger receptor class B, member 2
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scarb2multiple interactionsEXP 6480464CTD[Genistein co-treated with Diethylhexyl Phthalate] results in increased expression of SCARB2 mRNAPMID:36674726
Scarb2decreases expressionISOSCARB2 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of SCARB2 proteinPMID:31163220
Scarb2multiple interactionsISOScarb2 (Mus musculus)6480464CTD[Diethylhexyl Phthalate affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of SCARB2 mRNA; Diethylhexyl Phthalate inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of SCARB2 mRNA]PMID:29718165
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