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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621863
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf4
Name: activating transcription factor 4
Acc ID: CHEBI:42265
Term: epoxomicin
Definition: A tripeptide consisting of an Ile-Ile-Thr-NH2 sequence N-substituted on the threonamide amidic nitrogen with a (2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl group and with acetyl and methyl groups on the nitrogen of the isoleucine residue distal to the threonamide; a naturally occurring selective proteasome inhibitor with anti-inflammatory activity.
Chemical ID: MESH:C078846
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf4multiple interactionsISOAtf4 (Mus musculus)6480464CTDepoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ATF4 protein]]PMID:25639565
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