Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	621812
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Cxcl3
Name:	C-X-C motif chemokine ligand 3

Acc ID:	CHEBI:41879
Term:	dexamethasone
Definition:	A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID:	MESH:D003907

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Cxcl3	decreases expression	ISO	Cxcl3 (Mus musculus)	6480464	CTD	Dexamethasone results in decreased expression of CXCL1 mRNA	PMID:22733784
Cxcl3	multiple interactions	ISO	Cxcl3 (Mus musculus)	6480464	CTD	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CXCL1 mRNA; [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CXCL1 mRNA]; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL1 mRNA; Dexamethasone inhibits the reaction [[Ovalbumin co-treated with aluminum sulfate] results in increased secretion of CXCL1 protein]; Dexamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]; Dexamethasone inhibits the reaction [Silicon Dioxide results in increased expression of CXCL1 mRNA]; DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]]; DUSP1 gene mutant form promotes the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CXCL1 mRNA]; TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CXCL1 mRNA]	PMID:16054899 PMID:16880258 PMID:21414392 PMID:23503329 PMID:27568862 PMID:27660012 PMID:30849337

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