Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621812
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
Acc ID: CHEBI:35455
Term: 1-naphthyl isothiocyanate
Definition: An isothiocyanate that has formula C11H7NS.
Chemical ID: MESH:D015058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl3increases expressionEXP 6480464CTD1-Naphthylisothiocyanate results in increased expression of CXCL3 mRNAPMID:30723492
Cxcl3increases expressionISOCxcl3 (Mus musculus)6480464CTD1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA; 1-Naphthylisothiocyanate results in increased expression of CXCL1 proteinPMID:21070799 PMID:22094456 PMID:22157104 PMID:27853831 PMID:36460194
Cxcl3multiple interactionsISOCxcl3 (Mus musculus)6480464CTD[3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1,2-benzisoxazol-6-yl)methoxy)phenyl)propionic acid co-treated with C188-9 compound] inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA]; [FGA gene mutant form results in increased susceptibility to 1-Naphthylisothiocyanate] which results in increased expression of CXCL1 mRNA; C188-9 compound inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA]; pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA]; PPARA protein affects the reaction [pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA]]; Progesterone promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA]PMID:21356363 PMID:22157104 PMID:27853831 PMID:36460194
Go Back to source page   Continue to Ontology report