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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621803
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd17b2
Name: hydroxysteroid (17-beta) dehydrogenase 2
Acc ID: CHEBI:28955
Term: 2-methoxy-17beta-estradiol
Definition: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.
Chemical ID: MESH:C022830
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd17b2decreases response to substanceISOHSD17B2 (Homo sapiens)6480464CTDHSD17B2 protein results in decreased susceptibility to 2-MethoxyestradiolPMID:16397246
Hsd17b2multiple interactionsISOHSD17B2 (Homo sapiens)6480464CTD[HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-Methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestronePMID:16397246
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