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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp12multiple interactionsEXP 6480464CTD[Melatonin co-treated with Aluminum Chloride] results in decreased expression of CASP12 protein; Melatonin inhibits the reaction [Galactose results in increased expression of CASP12 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased cleavage of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased expression of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of CASP12 protein]PMID:17645694 PMID:18715270 PMID:28070110 PMID:33130240 PMID:34673010
Casp12multiple interactionsISOCasp12 (Mus musculus)6480464CTDMelatonin inhibits the reaction [bisphenol A results in increased expression of CASP12 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CASP12 protein]PMID:30910607 PMID:38538260
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