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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ddit4
Name: DNA-damage-inducible transcript 4
Acc ID: CHEBI:69120
Term: withaferin A
Definition: A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity.
Chemical ID: MESH:C009684
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit4increases expressionISODDIT4 (Homo sapiens)6480464CTDwithaferin A results in increased expression of DDIT4 proteinPMID:21266191
Ddit4multiple interactionsISODDIT4 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein]PMID:21266191
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