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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621568
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Asah1
Name: N-acylsphingosine amidohydrolase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Asah1affects expressionISOAsah1 (Mus musculus)6480464CTDBenzo(a)pyrene affects the expression of ASAH1 mRNAPMID:22342234
Asah1affects methylationISOASAH1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ASAH1 promoterPMID:27901495
Asah1increases expressionISOAsah1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ASAH1 mRNAPMID:22228805
Asah1increases mutagenesisISOASAH1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of ASAH1 genePMID:25435355
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