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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621513
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctss
Name: cathepsin S
Acc ID: CHEBI:28001
Term: vancomycin
Definition: A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.
Chemical ID: MESH:D014640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctssincreases expressionEXP 6480464CTDVancomycin results in increased expression of CTSS mRNAPMID:18289764
Ctssdecreases expressionISOCtss (Mus musculus)6480464CTDVancomycin results in decreased expression of CTSS mRNAPMID:18930951
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