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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:77986
Term: dibenziodolium
Definition: An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.
Chemical ID: MESH:C007517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDdiphenyleneiodonium inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK8 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK8 protein]PMID:21391979 PMID:26514923 PMID:30766661
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