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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases phosphorylationEXP 6480464CTDGlucose results in increased phosphorylation of MAPK8 proteinPMID:19861503 PMID:34801538 PMID:37619648
Mapk8multiple interactionsEXP 6480464CTD[[Paraquat results in increased phosphorylation of MAPK8 protein] which results in decreased abundance of Insulin] which results in increased abundance of Glucose; Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]; Metformin inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]; Scopoletin inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]PMID:34801538 PMID:36394833 PMID:37619648
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDGlucose results in increased phosphorylation of MAPK8 proteinPMID:36928891
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDAnisomycin inhibits the reaction [rutecarpine inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]]; Glucose deficiency results in increased activity of and results in increased phosphorylation of MAPK8 protein; rutecarpine inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]PMID:14505347 PMID:36928891
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