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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTDacetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; AG 1879 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]PMID:20354174
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