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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:133246
Term: tetramethylpyrazine
Definition: A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).
Chemical ID: MESH:C017953
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDtetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]PMID:26404762
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