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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621476
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnn4
Name: potassium calcium-activated channel subfamily N member 4
Acc ID: CHEBI:145810
Term: insulin
Definition: A peptide hormone which consists of two polypeptide chains, A- and B- chains which are linked together by disulfide bonds. The amino acid sequence of insulin varies across species and certain segments of the molecule are highly conserved. In most species, the A chain consists of 21 amino acids and the B chain consists of 30 amino acids. In mammals, insulin is synthesised in the pancreas within the beta cells whereas in certain species of fish, the insulin-producing tissue is uniquely located in separate structures called Brockmann bodies.
Chemical ID: MESH:D007328
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnn4increases expressionEXP 401794561RGDinsulin increases expression of Kcnn4 mRNA and protein in vascular smooth muscle cells 
Kcnn4multiple interactionsEXP 401794561RGD2-(2-amino-3-methoxyphenyl)chromen-4-one inhibits the reaction [insulin increases expression of Kcnn4 mRNA and protein in vascular smooth muscle cells] 
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