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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il11
Name: interleukin 11
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il11multiple interactionsISOIL11 (Homo sapiens)6480464CTD[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL11 mRNA; [Folic Acid deficiency co-treated with Methotrexate] results in increased expression of IL11 mRNAPMID:22975265 PMID:24657277
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