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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptch1
Name: patched 1
Acc ID: CHEBI:191178
Term: goralatide
Definition: A tetrapeptide that is Ser-Asp-Lys-Pro in which the N-terminal amino group carries an acetyl group. It is selective inhibitor of primitive haematopoietic cell proliferation and exhibits anti-inflammatory, anti-fibrotic, and pro-angiogenic properties.
Chemical ID: MESH:C058504
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptch1multiple interactionsEXP 6480464CTD[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]PMID:31181250
Ptch1multiple interactionsISOPTCH1 (Homo sapiens)6480464CTD[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; goralatide inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]PMID:31181250
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