PTCH1 (patched 1) - Rat Genome Database

Name: PTCH1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: PTCH1 (patched 1) Homo sapiens

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Symbol:

PTCH1

Name:

patched 1

RGD ID:

1319156

HGNC Page

HGNC:9585

Description:

Enables several functions, including cholesterol binding activity; cyclin binding activity; and hedgehog family protein binding activity. Involved in several processes, including cellular response to cholesterol; chordate embryonic development; and regulation of DNA-templated transcription. Located in several cellular components, including Golgi apparatus; caveola; and perinuclear region of cytoplasm. Implicated in carcinoma (multiple); holoprosencephaly (multiple); nevoid basal cell carcinoma syndrome (multiple); and stomach cancer. Biomarker of several diseases, including colorectal adenoma; gastrointestinal system cancer (multiple); hyperglycemia; nasopharyngitis; and nevoid basal cell carcinoma syndrome.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

BCNS; BCNS1; FLJ26746; FLJ42602; HPE7; NBCCS; patched homolog (drosophila); patched homolog 1; patched-like protein 1 delta10; patched-like protein 1 delta15; PTC; PTC1; PTCH; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH protein -3,4,5; PTCH11

RGD Orthologs

Alliance Orthologs

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Ptch1 (patched 1)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Ptch1 (patched 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Ptch1 (patched 1)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	PTCH1 (patched 1)	NCBI	Ortholog
Canis lupus familiaris (dog):	PTCH1 (patched 1)	HGNC	Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ptch1 (patched 1)	NCBI	Ortholog
Sus scrofa (pig):	PTCH1 (patched 1)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	LOC103219825 (protein patched homolog 1)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Ptch1 (patched 1)	NCBI	Ortholog
Other homologs ²
Mus musculus (house mouse):	Ptch2 (patched 2)	HGNC	OrthoMCL
Rattus norvegicus (Norway rat):	Pax8 (paired box 8)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Ptch1 (patched 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ptch1 (patched 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ptch1 (patched 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	ptc-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ptc	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ptc-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	ptch1.L	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	ptch1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	ptch1.S	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	95,442,980 - 95,516,971 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	95,442,980 - 95,517,057 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	98,205,262 - 98,279,253 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	97,245,085 - 97,319,068 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	95,285,954 - 95,350,386	NCBI
Celera	9	68,646,306 - 68,719,962 (-)	NCBI		Celera
Cytogenetic Map	9	q22.32	NCBI
HuRef	9	67,814,741 - 67,888,045 (-)	NCBI		HuRef
CHM1_1	9	98,351,712 - 98,425,709 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	107,612,621 - 107,686,610 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

Imported Human Phenotype Annotations - HPO

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