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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:28487
Term: reserpine
Definition: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Chemical ID: MESH:D012110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3decreases activityISONr1i3 (Mus musculus)6480464CTDReserpine results in decreased activity of NR1I3 proteinPMID:30203046
Nr1i3multiple interactionsISONR1I3 (Homo sapiens)6480464CTD[Reserpine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNAPMID:17041008
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