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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621357
Species: Rattus norvegicus
RGD Object: Gene
Symbol: E2f5
Name: E2F transcription factor 5
Acc ID: CHEBI:42223
Term: emodin
Definition: A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Chemical ID: MESH:D004642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
E2f5increases expressionISOE2F5 (Homo sapiens)6480464CTDEmodin results in increased expression of E2F5 mRNAPMID:16045814
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