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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:80883
Term: Ophiopogonin D
Definition: A steroid saponin that has formula C44H70O16.
Chemical ID: MESH:C046996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTD[ophiopogonin D co-treated with TGFB1 protein] results in decreased expression of and results in decreased activity of MMP9 protein; ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of MMP9 protein]]; ophiopogonin D inhibits the reaction [TGFB1 protein results in increased expression of MMP9 protein]PMID:32818624
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