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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:164200
Term: triclosan
Definition: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Chemical ID: MESH:D014260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDTriclosan results in increased expression of MMP2 mRNA; Triclosan results in increased expression of MMP2 proteinPMID:28844962 PMID:30510588
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of MMP2 protein]; fulvestrant inhibits the reaction [Triclosan results in increased expression of MMP2 protein]PMID:28844962
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