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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621295
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mvk
Name: mevalonate kinase
Acc ID: CHEBI:48861
Term: 2-trans,6-trans,10-trans-geranylgeranyl diphosphate
Definition: The all-trans-isomer of geranylgeranyl diphosphate.
Chemical ID: MESH:C002963
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mvkdecreases activityISOMVK (Homo sapiens)6480464CTDgeranylgeranyl pyrophosphate results in decreased activity of MVK proteinPMID:9392419
Mvkdecreases chemical synthesisISOMVK (Homo sapiens)6480464CTDMVK protein mutant form results in decreased chemical synthesis of geranylgeranyl pyrophosphatePMID:24073415
Mvkmultiple interactionsISOMVK (Homo sapiens)6480464CTDgeranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]PMID:9392419
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