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GENE - TERM ANNOTATION REPORT

RGD ID: 621255
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ago2
Name: argonaute RISC catalytic component 2
Acc ID: GO:0035278
Term: miRNA-mediated gene silencing by inhibition of translation
Definition: An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs.
Definition Source(s): PMID:14744438, PMID:15196554
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ago2involved_inISOAGO2 (Homo sapiens)1624291RGD PMID:17671087 PMID:18771919 PMID:19801630 PMID:23409027

PMID:17671087 PMID:18771919 PMID:19801630 PMID:23409027
Ago2involved_inIEAUniRule:UR0001075601600115UniProtGO_REF:0000104

GO_REF:0000104
Ago2involved_inISSUniProtKB:Q9UKV81600115UniProtGO_REF:0000024

GO_REF:0000024
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