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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621248
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acaca
Name: acetyl-CoA carboxylase alpha
Acc ID: CHEBI:78510
Term: dorsomorphin
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Chemical ID: MESH:C516138
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acacamultiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [azoxystrobin results in increased phosphorylation of ACACA protein]; dorsomorphin inhibits the reaction [mangiferin results in increased phosphorylation of ACACA protein]PMID:22292039 PMID:24726979
Acacadecreases expressionISOACACA (Homo sapiens)6480464CTDdorsomorphin results in decreased expression of ACACA protein modified formPMID:33838154
Acacadecreases phosphorylationISOACACA (Homo sapiens)6480464CTDdorsomorphin results in decreased phosphorylation of ACACA proteinPMID:32409581
Acacamultiple interactionsISOACACA (Homo sapiens)6480464CTD[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACACA mRNA; dorsomorphin inhibits the reaction [caryophyllene results in increased phosphorylation of ACACA protein]; dorsomorphin inhibits the reaction [pachymic acid results in increased phosphorylation of ACACA protein]; dorsomorphin inhibits the reaction [PRKAA1 protein results in increased phosphorylation of ACACA protein]; dorsomorphin inhibits the reaction [PRKAA2 protein results in increased phosphorylation of ACACA protein]; dorsomorphin inhibits the reaction [Resveratrol results in increased phosphorylation of ACACA protein]; dorsomorphin inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein]PMID:19625624 PMID:21778691 PMID:23465592 PMID:27188386 PMID:27234712 PMID:35524978
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