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ONTOLOGY REPORT - ANNOTATIONS


Term:dorsomorphin
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Accession:CHEBI:78510 term browser browse the term
Definition:A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Synonyms:exact_synonym: 6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
 related_synonym: Formula=C24H25N5O;   InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2;   InChIKey=XHBVYDAKJHETMP-UHFFFAOYSA-N;   SMILES=C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1;   compound C
 alt_id: MESH:C516138
 xref: CAS:866405-64-3 "ChemIDplus";   DrugBank:DB08597;   LINCS:LSM-3207
 xref_mesh: MESH:C516138
 xref: PDBeChem:TAK;   PMID:18026094 "Europe PMC";   PMID:18682835 "Europe PMC";   PMID:19996563 "Europe PMC";   PMID:20691279 "Europe PMC";   PMID:21384475 "Europe PMC";   PMID:21543851 "Europe PMC";   PMID:21988724 "Europe PMC";   PMID:23526253 "Europe PMC";   PMID:23936500 "Europe PMC";   PMID:24280125 "Europe PMC";   PMID:24396733 "Europe PMC";   Reaxys:11725482 "Reaxys"


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Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          antagonist 15784
            bone morphogenetic protein receptor antagonist 5639
              dorsomorphin 5639
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organic heteropolycyclic compound 17423
                                    organic heterobicyclic compound 15889
                                      pyrazolopyrimidine 5674
                                        dorsomorphin 5639
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.