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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dorsomorphin
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Accession:CHEBI:78510 term browser browse the term
Definition:A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Synonyms:exact_synonym: 6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
 related_synonym: Formula=C24H25N5O;   InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2;   InChIKey=XHBVYDAKJHETMP-UHFFFAOYSA-N;   SMILES=C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1;   compound C
 alt_id: MESH:C516138
 xref: CAS:866405-64-3;   DrugBank:DB08597;   LINCS:LSM-3207
 xref_mesh: MESH:C516138
 xref: PDBeChem:TAK;   PMID:18026094;   PMID:18682835;   PMID:19996563;   PMID:20691279;   PMID:21384475;   PMID:21543851;   PMID:21988724;   PMID:23526253;   PMID:23936500;   PMID:24280125;   PMID:24396733;   PMID:35782765;   PMID:38500971;   Reaxys:11725482


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    Path 1
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      CHEBI ontology 19909
        role 19880
          biological role 19878
            pharmacological role 19113
              antagonist 17261
                bone morphogenetic protein receptor antagonist 5702
                  dorsomorphin 5702
    Path 2
    Term Annotations click to browse term
      CHEBI ontology 19909
        subatomic particle 19907
          composite particle 19907
            hadron 19907
              baryon 19907
                nucleon 19907
                  atomic nucleus 19907
                    atom 19907
                      main group element atom 19846
                        p-block element atom 19846
                          carbon group element atom 19784
                            carbon atom 19781
                              organic molecular entity 19781
                                organic molecule 19735
                                  organic cyclic compound 19528
                                    organic heterocyclic compound 18895
                                      organic heteropolycyclic compound 18318
                                        organic heterobicyclic compound 17258
                                          pyrazolopyrimidine 5754
                                            dorsomorphin 5702
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