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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:38940
Term: sunitinib
Definition: A pyrrole that has formula C22H27FN4O2.
Chemical ID: MESH:C473478
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1decreases expressionISOCol1a1 (Rattus norvegicus)6480464CTDsunitinib results in decreased expression of COL1A1 mRNAPMID:24321339
Col1a1decreases expressionISOCOL1A1 (Homo sapiens)6480464CTDSunitinib results in decreased expression of COL1A1 mRNAPMID:27235791 PMID:31533062
Col1a1increases expressionISOCol1a1 (Rattus norvegicus)6480464CTDsunitinib results in increased expression of COL1A1 mRNAPMID:26581635
Col1a1multiple interactionsISOCol1a1 (Rattus norvegicus)6480464CTDCarnitine inhibits the reaction [sunitinib results in increased expression of COL1A1 mRNA]PMID:26581635
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