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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1multiple interactionsEXP 6480464CTDthymoquinone inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]; thymoquinone inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]PMID:27375216 PMID:27688165 PMID:31935363
Col1a1multiple interactionsISOCol1a1 (Rattus norvegicus)6480464CTDthymoquinone inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]PMID:38504479
Col1a1multiple interactionsISOCOL1A1 (Homo sapiens)6480464CTDthymoquinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]PMID:27688165
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