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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621083
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd2
Name: cyclin D2
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd2decreases expressionEXP 6480464CTDMetformin results in decreased expression of CCND2 proteinPMID:16760380
Ccnd2multiple interactionsEXP 6480464CTDMetformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein]PMID:16760380
Ccnd2multiple interactionsISOCCND2 (Homo sapiens)6480464CTD[Paclitaxel co-treated with Metformin] results in decreased expression of CCND2 mRNAPMID:29309887
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