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GENE - TERM ANNOTATION REPORT

RGD ID: 621074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sfrp1
Name: secreted frizzled-related protein 1
Acc ID: GO:0090090
Term: negative regulation of canonical Wnt signaling pathway
Definition: Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
Definition Source(s): GOC:dph, GOC:tb
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sfrp1acts_upstream_of_or_withinISOSfrp1 (Mus musculus)1624291RGDMGI:108078 MGI:1329040 MGI:98956 PMID:17462603 PMID:18257070 PMID:19850029 PMID:19896444

PMID:17462603 PMID:18257070 PMID:19850029 PMID:19896444
Sfrp1involved_inISOSFRP1 (Homo sapiens)1624291RGDUniProtKB:P27467 PMID:10347172 PMID:16149051 PMID:16288033 PMID:16532032 PMID:17035233 PMID:17443492 PMID:17462603 PMID:17471511 PMID:17994217 PMID:19072540 PMID:19095296 PMID:19254787 PMID:19277043 PMID:19569235 PMID:24080158 PMID:9391078 PMID:9724099

PMID:10347172 PMID:16149051 PMID:16288033 PMID:16532032 PMID:17035233 PMID:17443492 PMID:17462603 PMID:17471511 PMID:17994217 PMID:19072540 PMID:19095296 PMID:19254787 PMID:19277043 PMID:19569235 PMID:24080158 PMID:9391078 PMID:9724099
Sfrp1involved_inISOSfrp1 (Mus musculus)1624291RGD PMID:16149051

PMID:16149051
Sfrp1involved_inIEAUniProtKB:Q8C4U3 or ensembl:ENSMUSP000000339521600115EnsemblGO_REF:0000107

GO_REF:0000107
Sfrp1involved_inIEAUniProtKB:Q8N474 or ensembl:ENSP000002207721600115EnsemblGO_REF:0000107

GO_REF:0000107
Sfrp1involved_inIDA 4107087UniProtPMID:16149051

 
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