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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sfrp1
Name: secreted frizzled-related protein 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sfrp1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of SFRP1 mRNAPMID:21839799
Sfrp1affects methylationISOSFRP1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of SFRP1 3' UTR; Benzo(a)pyrene affects the methylation of SFRP1 promoterPMID:27901495
Sfrp1decreases expressionISOSfrp1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of SFRP1 mRNAPMID:21803694
Sfrp1decreases methylationISOSFRP1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of SFRP1 exonPMID:27901495
Sfrp1increases methylationISOSfrp1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of SFRP1 intronPMID:27901495
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