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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:52646
Term: leptomycin B
Definition: A leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17.
Chemical ID: MESH:C038753
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1decreases expressionISODNMT1 (Homo sapiens)6480464CTDleptomycin B results in decreased expression of DNMT1 mRNAPMID:20803015
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTD[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of DNMT1 mRNAPMID:20803015
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