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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1multiple interactionsEXP 6480464CTD[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNAPMID:28964809
Dnmt1decreases expressionISODNMT1 (Homo sapiens)6480464CTDGenistein results in decreased expression of DNMT1 mRNA; Genistein results in decreased expression of DNMT1 proteinPMID:16705744 PMID:19221000 PMID:23593078
Dnmt1increases expressionISODNMT1 (Homo sapiens)6480464CTDGenistein results in increased expression of DNMT1 mRNAPMID:30684530
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTDsulforaphane inhibits the reaction [Genistein results in increased expression of DNMT1 mRNA]PMID:30684530
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