GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Dnmt1 | decreases expression | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of DNMT1 mRNA | PMID:22952798 | Dnmt1 | decreases phosphorylation | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased phosphorylation of DNMT1 protein | PMID:27026707 | Dnmt1 | increases expression | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of DNMT1 mRNA | PMID:30684530 PMID:32030086 | Dnmt1 | multiple interactions | ISO | DNMT1 (Homo sapiens) | 6480464 | CTD | 6-prenylnaringenin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]; [Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]; [sodium arsenite co-treated with Estradiol] results in decreased expression of DNMT1 mRNA; Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]; Plant Extracts inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]; Resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]; sulforaphane inhibits the reaction [Estradiol results in increased expression of DNMT1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]] | PMID:20631324 PMID:22952798 PMID:30684530 PMID:32986415 | | ||||||||||||||||||||||
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