GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mlh1 | decreases expression | ISO | MLH1 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of MLH1 mRNA; Estradiol results in decreased expression of MLH1 protein | PMID:22082530 PMID:23804311 | Mlh1 | multiple interactions | ISO | MLH1 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with sodium arsenite] results in decreased expression of MLH1 mRNA; [Estradiol results in increased expression of MLH1 mRNA] which results in increased susceptibility to Cisplatin; [Estradiol results in increased expression of MLH1 mRNA] which results in increased susceptibility to Doxorubicin; [sodium arsenite co-treated with Estradiol] results in decreased expression of MLH1 protein; [sodium arsenite co-treated with Estradiol] results in increased methylation of MLH1 promoter; decitabine affects the reaction [Estradiol results in decreased expression of MLH1 mRNA] | PMID:22082530 PMID:23804311 PMID:28323900 | | ||||||||||||||||||||||
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