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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620925
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1adecreases expressionEXP 6480464CTDTestosterone results in decreased expression of PPARGC1A mRNAPMID:16954335
Ppargc1amultiple interactionsEXP 6480464CTDNorepinephrine inhibits the reaction [Testosterone results in decreased expression of PPARGC1A mRNA]; Testosterone inhibits the reaction [Dexamethasone results in decreased expression of PPARGC1A protein]PMID:16954335 PMID:21094144
Ppargc1aincreases expressionISOPpargc1a (Mus musculus)6480464CTDTestosterone results in increased expression of PPARGC1A mRNAPMID:21045173
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