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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62092
Species: Mus musculus
RGD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2aaffects response to substanceEXP 6480464CTDHTR2A protein affects the susceptibility to FluoxetinePMID:10773209
Htr2adecreases activityEXP 6480464CTDFluoxetine results in decreased activity of HTR2A proteinPMID:19445393 PMID:20464512
Htr2aincreases expressionEXP 6480464CTDFluoxetine results in increased expression of HTR2A mRNAPMID:21083617
Htr2aaffects expressionISOHtr2a (Rattus norvegicus)6480464CTDFluoxetine affects the expression of HTR2APMID:26475043
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